Alas I think for many this is taken too literally. How do we reconcile another grand life philosophy - the one that reminds us that doing the same thing over again and expecting a different result is, frankly, madness.
Many of us have taken the road less traveled at various junctures of our life and found ourselves heading into the wilderness. Blindly committing to a path and expecting it to lead to the promised land purely by virtue of never giving up, is of course pointless.
Sometimes our greatest life changes manifest after we swallow our pride and make a decision to admit 'defeat' and start over. Inverted commas, indicating that defeat is merely contextual. Nothing was ever achieved without some feedback via bruises, and temporary set backs, all a necessary part of the journey.
Disfunctional relationships, family, romantic or fleeting friendships are rarely empowering by virtue of just hanging in and persevering.
Let's be less literal. Never ever give up (as Winstone Churchill evoked) on your aspirations and ambitions. If you are a dreamer, never quit dreaming. If you have a lifelong passion, by all means saturate yourself in the energy to fuel your focus and inspire your persistence.
To be, do and have more, is an innate driver that requires an uncommon mindset. To believe in and visualise a future beyond peer expectation is a fragile gift.
Covet your BIG dreams and goals - write them down, day dream, talk about them, surround yourself with those similarly afflicted, risk set backs, change direction, jump off the treadmill, accept that the GPS may need recalibrating and beware of taking memes too literally!